The Chicago Cubs won back-to-back World Series titles in 1907 and 1908.
They have not been crowned champions since.
But after signing Jon Lester to a six-year, $155 million contract, the oddsmakers in Las Vegas think the 106-year drought could be coming to an end soon.
On Wednesday morning, Bovada.lv released an updated "Odds to win the 2015 World Series," and the Cubs now sit at 12 to 1 -- tied with the Tigers and Angels for the fourth best mark.
The Cubs began the offseason at 40 to 1 and and jumped to 18 to 1 after hiring Joe Maddon as manager.
The Giants, who have won three of the last five Fall Classics, currently possess 14 to 1 odds.
The Dodgers, who have won two straight NL West titles, own the best odds at 17 to 2.
The Red Sox, who signed Pablo Sandoval and Hanley Ramirez, are second at 9 to 1, followed by the Nationals at 10 to 1.