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DENVER -- Peyton Manning's receivers played keep-away with his milestone memento and the NFL's new leader in career touchdown passes toyed with the San Francisco 49ers in the Denver Broncos' emphatic 42-17 victory Sunday night.
Manning went into the showdown two TDs shy of Brett Favre's record of 508 and threw four touchdown passes, giving him 510.
"It is quite an honor," Manning said. "I do have great appreciation for quarterbacks who played this game throughout the years. It's very humbling, has taken a lot of hard work, a lot of people helped me get to this point."
Manning surpassed Favre's mark with an 8-yard strike to Demaryius Thomas late in the second quarter. As he went to retrieve the football, his teammates decided to have some fun.
Thomas tossed the historic ball over Manning and to Emmanuel Sanders, who then lobbed it to Wes Welker. From there, Welker dished it back to Sanders, who then flipped it to Julius Thomas - all of Manning's favorite targets getting into the act.
[WHAT THEY'RE SAYING: Manning breaks Favre's record]
"I heard whispers about something," Manning said. "Those guys are all great athletes and my vertical leap isn't what it used to be. I haven't played keep-away since I was 8 years old. That is something I will always remember."
Finally, Manning got the ball along with congratulations from his teammates and coaches. The souvenir won't end up on Manning's mantle, however - the Pro Football Hall of Fame has a nice spot all ready for it.
During the celebration on the sideline, Manning watched the giant scoreboard high above him in the south end zone as his boss, GM John Elway, and then Favre, offered their kudos.
"I want to say congratulations for breaking the touchdown record," Favre said. "I'm not surprised. You've been a wonderful player and I've enjoyed watching you play. I've enjoyed competing against you. I wish you great success for the rest of the season and the rest of your career."
Manning added a 40-yard TD throw to Thomas after Aqib Talib's interception in the third quarter that made it 28-10, and then Thomas set up another score with a 49-yard catch.
This time, running back Ronnie Hillman darted through the line for a career-long 37-yard run that made it 35-10. He added a 1-yarder as the Broncos (5-1) finally found a ground game to go with Manning's passing prowess.
Manning completed 22 of 26 passes for 318 yards with no interceptions to go with his four TD throws.
Demaryius Thomas caught eight of those throws for 171 yards, giving him an eye-popping 521 yards receiving and five TDs over the last three games.
The 49ers (4-3) did very little right in seeing their three-game winning streak snapped. Their only real highlight was Colin Kaepernick's 4-yard TD pass to Stevie Johnson with 11 seconds left in the half brought the 49ers to 21-10.
Kaepernick completed 24 of 39 passes for 263 yards with one TD and one interception. He was sacked six times - DeMarcus Ware had three and Von Miller two.
His backup, Blaine Gabbert, threw a 20-yard TD pass to Bruce Ellington with a minute left.
This night belonged the Manning from start to finish.
He threw a 3-yard TD pass to Sanders on Denver's first drive and tied the record when Welker took a pass over the middle for 39 yards. Sanders' score was his first in Denver, and he became the 47th player to catch a TD pass from Manning.
Manning reached the milestone in his 246th regular-season game. Favre needed 302.
"I think Brett has always known he is one of my favorite players. He played the position with so much passion, so much toughness and great production as a quarterback," Manning said. "I am honored to join this club with him."
As Manning approached the milestone, Favre told The Associated Press he was thrilled "it's Peyton that's doing it."
The veneration is mutual, Manning said.
Saying he appreciated Favre's words of encouragement, Manning suggested that of all the men who have ever taken a snap in the 94-year history of the NFL, "nobody's defined longevity and career toughness more than him."
Among those offering their congratulations on the scoreboard during the game was Fran Tarkenton, who said, "Well, Peyton, it's official. Your ducks have crossed the end zone more than anybody else's. But really, congratulations. Nobody has ever played the quarterback position better than you have."
Notes: This marked the first game for S.F. with 40-plus passes since Sept. 26, 2010, snapping a 67-game streak, the longest in the league since 1978. ... Paul Cornick replaced Chris Clark at RT for Denver and drew a false start flag on the Broncos' second snap. He also was beaten by LB Aaron Lynch for a sack on the last play of the first quarter. ... Miller extended his NFL-best sack streak to five games. ... 49ers C Daniel Kilgore was carted off the field with a left leg and ankle injury in the third quarter. ... The Broncos lost LB Steven Johnson (ankle) and CB Omar Bolden (possible concussion).