Operating without starters DeMarcus Cousins and Darren Collison, the Kings battled, yet fell to the Spurs 107-96 on Friday at Sleep Train Arena.
The Kings trailed the Spurs by two points entering the fourth quarter and Rudy Gay ended a three-plus minute scoring drought by draining two free throws to tie the game at 80.
However, the Spurs took control outscoring Sacramento 27-16 over the remainder of the game to secure the road victory.
Tony Parker led the Spurs (35-23) with 19 points while Kawhi Leonard (17), Manu Ginobili (16) and Tim Duncan (12) were also in double figures in the winning effort.
Ben McLemore led the Kings (20-36) with 21 points while Ray McCallum added a season-high 20 points. Rudy Gay also contributed 16 points and six rebounds.
Jason Thompson secured his second consecutive double-double, scoring 12 points and securing 11 rebounds. Andre Miller rounded out the Sacramento double-figure scorers chipping in with 10 points.
Sacramento was without their starting center in Cousins, due to a left ankle sprain and left hip contusion, and point guard Collison, who was out due to injury for his eighth consecutive game. Collison is likely facing surgery next week to repair a core muscle strain.
[HERENDA: Collison set for surgery, season in jeopardy]
Sacramento is now 2-11 this season without Cousins.
The Kings are now 2-2 under Karl. They fall to 13-18 at home and have failed to win back-to-back games since a three-game winning streak in November.
The Spurs snapped a four-game losing streak, playing in their eighth consecutive road game, and improved to 15-16 on the road.
Last year’s NBA champion Spurs also take a 2-1 season series advantage against Sacramento, as the squad’s will meet for a fourth and final time this campaign on Wednesday at the At&T Center.
Sacramento got off to another auspicious start from the floor as they were 10-for-14 from the floor early and lead 20-10.
The Kings held a 39-31 lead at the 4:30 mark of the second quarter, but the Spurs went on a 18-8 run to lead 49-46 at the half.
Tony Parker led the Spurs with 19 points including 17 in the second half. The Spurs floor general also dished four assists and secured five rebounds for San Antonio.
With the game tied at 80 in the fourth quarter, San Antonio outscored Sacramento 27-16 to secure the win.
Kings -- G Darren Collison (right hip flexor strain), and F Eric Moreland (left shoulder labral tear) are out while C DeMarcus Cousins (left ankle sprain and left hip contusion) was doubtful and did not play.
Spurs -- None to report.
The Kings three game homestand concludes with Sacramento hosting Portland on Sunday.