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Coach Jim Harbaugh had his final conference call before kickoff weekend, thoroughly addressing the state of the 49ers.
The Astros have fired manager Bo Porter and bench coach Dave Trembley, while coach Tom Lawless has been assigned the interim manager tag.
The Houston Texans gave up a 2016 conditional seventh-round pick to acquire quarterback Ryan Mallett from the New England Patriots.
Dustin Ackley homered and drove in four runs and the Seattle Mariners averted a three-game sweep to beat the Washington Nationals 5-3.
The White Sox took advantage of Detroit's shaky defense to beat the Tigers 6-2 after trading Adam Dunn to the A's Sunday afternoon.
Matt Holliday rallied St. Louis in the eighth past the Cubs for the 9-6 win, and are tied with the Giants in the NL Wild Card standings.
The Dodgers avoid a three-game sweep with 7-1 win over the Padres, and remain 2.5 games ahead of the Giants in the NL West.
After struggling as a No. 1 overall pick, then surging only to be replaced by a younger QB, Alex Smith finally landed his career-defining contract with the Chiefs.
Former 49ers continue to land jobs around the NFL, with the latest being special teams ace C.J. Spillman, who looks to join the Cowboys.
The Giants swept the NL Central leading Brewers Sunday, as Pablo Sandoval and Hunter Pence combined for seven hits, six runs and five RBI.
Scott Kazmir surrendered six runs in the second inning, and the A's offense sputtered again as they were swept by Angels with an 8-1 loss.