Cornerback Chris Cook and center Daniel Kilgore were placed on season-ending injured reserve, the 49ers announced on Saturday.
The Sharks are looking to end a three-game skid, but the 1-7-0 Sabres have their own motivation heading into Saturday's game at the SAP Center.
The Kings accomplished their goal of taking the final preseason game, and did so in clutch fashion, but were unfortunately dinged up in the process.
Down 2-1 in the World Series, Bruce Bochy will manage with urgency, but will not shy away from sticking with his original Game 4 starter.
Marcus Mariota went on a tear Friday night vs. Cal, matching his season-high with five TD passes in a 59-41 victory over Jared Goff and the Bears.
Bruce Bochy is more reluctant to quit on Ryan Vogelsong than he is starting Madison Bumgarner on short rest, getting away from his normal rotation.
Klay Thompson took the reigns in the Warriors' preseason finale, dropping 35 points as Golden State defeated the Denver Nuggets 119-112.