Solid passing by Joe Pavelski and Brent Burns led to a Patrick Marleau goal to give the Sharks a 2-1 lead over the Senators in the second period.
Kruize Pinkins scored 18 points and San Francisco made a second half surge to take control and beat Pacific 65-55 on Saturday.
Jared Brownridge made a layup with seven seconds left to lift Santa Clara to 71-70 upset win over Sain't Mary's on Saturday.
The Sharks had a 2-1 lead entering the third, but the Senators scored three times to hand San Jose their eighth straight loss at home.
San Jose State fell to 0-16 in conference play with a 62-51 loss to Nevada in Rano on Saturday.
Free agent outfielder Dayan Viciedo has reportedly agreed to a minor league deal with the Toronto Blue Jays.
13-year NBA veteran Anthony Mason passed away on Saturday. Members of the Warriors and Kings took to Twitter to pay their respects.
Thunder guard Russell Westbrook had surgery to repair a fracture to his right cheek after getting hit by a teammate's knee.