SAN DIEGO -- Ichiro Suzuki singled in the first inning and doubled in the ninth to raise his hits total in the Japanese and North American major leagues to 4,257, passing Pete Rose's record Major League Baseball total during the Miami Marlins' 6-3 loss to the San Diego Padres.
Suzuki had 1,278 hits for Orix in Japan's Pacific League (1992-00) and the rest with Seattle, the New York Yankees and Marlins.
Luis Perdomo (2-2) allowed three runs and six hits in six innings. It was the fourth big league start for the 23-year-old right-hander, taken by Colorado from St. Louis in December's winter meeting draft and acquired by the Padres later that day.
Fernando Rodney pitched a two-hit ninth to remain perfect in 13 save chances. The Padres won for just the second time in 21 series finales and for the fourth time in 22 day games.
Justin Nicolino (2-4) gave up five runs and 10 hits in 4 2/3 innings.
Suzuki reached on a dribbler up the first-base line in the first. Catcher Derek Norris made a sliding attempt to field the ball and throw it in one motion, but Suzuki had already raced past the bag. Suzuki advanced to second on Martin Prado's single and scored on Christian Yelich's RBI single.
In the ninth, Suzuki lined a double into the right-field corner against Rodney, then took off his helmet and waved it to applauding fans. The sparse crowd, announced at 20,037, gave Suzuki a warm ovation as both teams' players applauded for Suzuki, as well.
Upton's second homer of the series tied the score in the second, and Miami took a 3-1 lead in the fourth on J. T. Realmuto's RBI single and Miguel Rojas' sacrifice fly.
Ryan Schimpf, called up from Triple-A on Tuesday, cut the gap with a sacrifice fly in the bottom half, and the Padres took a 5-3 lead in the fifth when Norris hit a two-run single and scored on Upton's single.
Miami had two on in the sixth when Myers ranged from first to make an over-the-shoulder catch on Miguel Rojas' two-out flare to shallow right field.
Padres: RHP Andrew Cashner (sore neck) remains on the disabled list and has yet to be cleared to start a throwing program.
Marlins: RHP Jose Fernandez will have his next start pushed back from Friday to Tuesday against the Atlanta Braves as the team monitors his innings in his return from Tommy John surgery.
Marlins: LHP Adam Conley (3-4 4.13) faces visiting Colorado in Friday's opener of a 10-game homestand. Conley has lost three of four decisions in Miami this season.