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SANTA CLARA -- Wide receiver Mario Manningham will not be eligible to play in the 49ers' first six regular-season games.
Coach Jim Harbaugh said Manningham, who is rehabbing from tears to his left anterior cruciate and posterior cruciate ligaments, will open the season on reserve/physically unable to perform.
Manningham, who sustained the injury Dec. 23 against the Seattle Seahawks, is making good progress, Harbaugh said. Manningham underwent surgery to repair the ligament damage a month later after the swelling subsided.
"It's going very well," Harbaugh said Sunday. "Been great feedback on Mario. He's really feeling now he can put his leg in the ground and generate some power.
"It's exciting and he's excited about it."
Manningham was the 49ers' second-leading receiver last season with 42 catches for 449 yards.
Harbaugh intimated wide receiver Michael Crabtree remains on pace for a possible late-season return after sustaining a torn Achilles' tendon in May. Crabtree had a team-leading 85 receptions for 1,105 yards and nine touchdowns last season.
"He's hit every single goal, as far as his timeline, so that's been real exciting and encouraging," Harbaugh said of Crabtree.
"Everything's been positive. There've been no setbacks with any of the players who've been on the PUP."
Both Crabtree, of course, will also be placed on reserve/PUP to open the season.
Under the NFL's new PUP rules, Crabtree and Manningham will be ineligible for the first six weeks of the regular season. Beginning after the sixth week (Oct. 15) and continuing through the conclusion of the 11th weekend of regular season games (Nov. 18), clubs are permitted to begin practicing players off their PUP list for no more than 21 days.
At any time during the 21-day practice period clubs may activate a player from the PUP list.