Week 1: Sunday, Sept. 8
Green Bay at 49ers, 1:25 p.m. (FOX)
The Packers went back to school, literally, in the offseason to learn about the intricacies of the read option after Colin Kaepernick humiliated them in the playoffs. Kaepernick rushed for 181 yards and two touchdowns -- the most ground yards from a quarterback in NFL history -- and he threw for 263 yards and two touchdowns in a 45-31 victory. Green Bay will not have to wait long to find out if they are capable of containing Kaepernick. The 49ers' pass defense will be tested, too, against Aaron Rodgers and the explosive Packers offense. This is the second straight year the 49ers have opened against Green Bay. Last year, the 49ers won at Lambeau Field.
Week 2: Sunday, Sept. 15
49ers at Seattle, 5:30 p.m. (NBC)
Is the Seahawks' home crowd in the 49ers' heads? Routinely, 49ers players talk about the difficulty of playing in the Seattle stadium because of the crowd noise. When the clubs met late last season in a nationally televised game, Pete Carroll's team won in a 42-13 rout. They'll face the Seahawks in another nationally televised game.
Week 3: Sunday, Sept. 22
Indianapolis at 49ers, 1:25 p.m. (CBS)
Jim Harbaugh recruited Colts second-year quarterback Andrew Luck to Stanford. Luck thrived in Greg Roman's offense with the Cardinal. Now, it's former Stanford defensive coordinator Vic Fangio who has the responsibility of designing a plan to slow down Luck, who led his team to an 11-5 record as a rookie -- an improvement of nine victories over the previous season.
Week 4: Thursday, Sept. 26
49ers at St. Louis, 5:25 p.m. (NFL Network)
The Rams won seven games last season in Jeff Fisher's first year with the organization. That included a 1-0-1 record against the 49ers. This year, the Rams should be even better if quarterback Sam Bradford continues to progress. The Rams can help themselves out in the draft with first-round selections at Nos. 16 and 22.
Week 5: Sunday, Oct. 6
Houston at 49ers, 5:30 p.m. (NBC)
It's another prime-time game for the 49ers. This is the Texans' first trip to San Francisco since the so-called "Bush Bowl" near the end of the 2005 season. As it turned out, Reggie Bush was not the prize of the 2006 draft. Houston selected Mario Williams with the No. 1 overall pick. He is now playing in Buffalo. The 49ers' pick at No. 6, Vernon Davis, is still a valuable member of the team.
Week 6: Sunday, Oct. 13
Arizona at 49ers, 1:25 p.m. (FOX)
Michael Crabtree has gotten the upper hand in his head-to-head meetings with young Cardinals cornerback Patrick Peterson. A year ago at Candlestick, Crabtree caught eight passes for 172 yards and two touchdowns.
Week 7: Sunday, Oct. 20
49ers at Tennessee, 1:05 p.m.(FOX)
The 49ers will visit an old friend. Tight end Delanie Walker, who served as Vernon Davis' backup in each of his seven seasons with the 49ers, signed a four-year contract as a free agent to be the Titans' starter. After this game, the 49ers will depart for their overseas trip to London.
Week 8: Sunday, Oct. 27
49ers vs. Jacksonville at Wembley Stadium, London, 10 a.m. (FOX)
The 49ers make their second trip to the United Kingdom in four seasons. In 2010, the 49ers defeated the Denver Broncos 24-16 at Wembley Stadium. They will most likely spend the entire week in the London area. It's a similar week-long trip to what the 49ers experienced the past two years in Youngstown, Ohio, to cut down on travel between back-to-back eastern games.
Week 9: BYE
Week 10: Sunday, Nov. 10
Carolina at 49ers, 1:05 p.m. (FOX)
"Plutonium-grade raw material" will be coming to Candlestick Park in its final season as the home of the 49ers. Coach Jim Harbaugh gave a glimpse into the kind of quarterback he wanted for the 49ers prior to the 2011 draft when he used those words to describe Cam Newton. The Panthers selected Newton with the No. 1 overall pick, and the 49ers traded up in the second round to choose Colin Kaepernick.
Week 11: Sunday, Nov. 17
49ers at New Orleans, 1:25 p.m. (FOX)
This is the 12th season the 49ers and Saints have no longer been members of the same division. And this is the ninth meeting between the clubs over that period. The 49ers also return to the scene of Super Bowl XLVII.
Week 12: Monday, Nov. 25
49ers at Washington, 5:40 p.m. (ESPN)
Quarterback Robert Griffin underwent surgery to repair two knee ligaments, including his ACL, on Jan. 9 after being removed from the Redskins' playoff loss to the Seattle Seahawks just days earlier. Last month, Dr. James Andrews, who performed the surgery, said Griffin is "superhuman" and his recovery is "way ahead of schedule." This is the second game of a back-to-back trip, but at least the 49ers have an extra day with a Monday night game.
Week 13: Sunday, Dec. 1
St. Louis at 49ers, 1:05 p.m. (FOX)
The Rams were the 49ers' first regular-season opponent at Candlestick Park in 1971 after moving out of Kezar Stadium. They will not be the last game, though. Last year, the 49ers and Rams played to a rare tie at Candlestick.
Week 14: Sunday, Dec. 8
Seattle at 49ers, 1:25 p.m. (FOX)
The Seahawks proved to be a difficult matchup for the 49ers last season even before Russell Wilson really asserted himself as a leader on offense. In one of the more physical games of the season, the 49ers outlasted Seattle 13-7 at Candlestick Park.
Week 15: Sunday, Dec. 15
49ers at Tampa Bay, 10 a.m. (FOX)
Wide receivers and tight ends should beware. There's a new player in the Buccaneers' secondary who is not afraid to hit wide receivers and tight ends to venture into the middle of the field. The Buccaneers targeted Dashon Goldson on the first day of free agency. After the 49ers declined to tag Goldson as their franchise player on a one-year $7.45 million contract, the Buccaneers awarded him a five-year deal that averages $8.25 million annually.
Week 16: Monday, Dec. 23
Atlanta at 49ers, 5:40 p.m. (ESPN)
The final regular-season game at Candlestick will be against an old NFC West opponent. Two weeks before Jim Harbaugh complained about the no-calls on passes intended for Michael Crabtree near the end of Super Bowl XLVII, the Falcons saw their season end against the 49ers in similar fashion. Linebacker NaVorro Bowman broke up a fourth-down pass intended for Roddy White to preserve the 49ers' 28-24 victory at the Georgia Dome. Matt Ryan threw for 396 yards and Julio Jones caught 182 yards in passes, but the 49ers shut out the Falcons in the second half of the NFC Championship Game.
Week 17: Sunday, Dec. 29
49ers at Arizona, 1:25 p.m. (FOX)
The Cardinals had one of the worst offensive lines in football last season. The major goal for first-year coach Bruce Arians is to keep quarterback Carson Palmer healthy in his new home . . . for the entire season.
49ers' 2013 preseason schedule:
San Francisco 49ers
Aug. 8 Denver (Thurs) 6 p.m.
Aug. 16 at Kansas Cit (Fri) 5 p.m.
Aug. 25 Minnesota (Sun) 5 p.m. (NBC)
Aug. 29 at San Diego (Thurs) 7 p.m.
Sep. 8 Green Bay Packers 1:25 p.m.
Sep. 15 at Seattle Seahawks 5:30 p.m.
Sep. 22 Indianapolis Colts 1:25 p.m.
Sep. 26 at St. Louis Rams (Thurs) 5:25 p.m.
Oct. 6 Houston Texans 5:30 p.m.
Oct. 13 Arizona Cardinals 1:25 p.m.
Oct. 20 at Tennessee Titans 1:05 p.m.
Oct. 27 at Jacksonville Jaguars (London) 10:00 a.m.
Nov. 3 BYE
Nov. 10 Carolina Panthers 1:05 p.m.
Nov. 17 at New Orleans Saints 1:25 p.m.
Nov. 25 at Washington Redskins (Mon) 5:40 p.m.
Dec. 1 St. Louis Rams 1:05 p.m.
Dec. 8 Seattle Seahawks 1:25 p.m.
Dec. 15 at Tampa Bay Buccaneers 10:00 a.m.
Dec. 23 Atlanta Falcons (Mon) 5:40 p.m.
Dec. 29 at Arizona Cardinals 1:25 p.m.