The 49ers aren't the only ones losing players before the start of the 2015 regular season — their opponents are, too.
Steelers second-year wideout Martavis Bryant was handed a four-game suspension Thursday.
The Clemson product was cited for failing several marijuana tests, according to multiple reports.
[RELATED: Reports: Cardinals' Iupati sidelined, may miss 49ers in Week 3]
Bryant, a 6-foot-4 long-strider, was set for a breakout campaign in Year 2 after averaging 21.1 yards per catch as a rookie.
He was slated to the be the No. 2 receiver opposite All-Pro receiver Antonio Brown.
Bryant expects to be unavailable for Week 2 when the Steelers host the San Francisco 49ers.
Bryant is currently appealing the suspension.
#Steelers WR Martavis Bryant is facing a four-game suspension for violating league's substance of abuse policy, per source.— Ross Jones (@RossJonesFOX) August 27, 2015
#Steelers WR Martavis Bryant’s looming 4-game suspension is for multiple failed marijuana tests, source said. Appeal is in the latter stages— Ian Rapoport (@RapSheet) August 27, 2015
Steelers WR Martavis Bryant is facing 4-game suspension for violating Substance Abuse Policy, per league sources. Suspension under appeal.— Adam Schefter (@AdamSchefter) August 27, 2015