Another NFC West team has been dealt a significant blow, as the Cardinals may have lost premier guard Mike Iupati for the first part of the season.
The three-time Pro Bowl lineman is set to undergo arthroscopic knee surgery that will sideline him 6-8 weeks, according to multiple reports.
Coach Bruce Arians told reporters Wednesday that there was swelling in Iupati's knee.
The 6-foot-5, 329-pound mauling interior lineman spent his first five seasons with the San Francisco 49ers after the team selected him with the No. 17 overall pick in 2010.
Iupati, 28, earned three Pro Bowl nods, was named a first-team All-Pro in 2012, and played in two NFC Championship games, as well as a Super Bowl.
The 49ers did not attempt to re-sign Iupati once his contract expired this past offseason.
Iupati signed a five-year, $40 million deal with the Cardinals, as Arizona looks to fortify the offensive line in front of quarterback Carson Palmer, and enhance their run game.
If Iupati is sideline the 6-8 weeks, he could miss the Week 3 matchup against his former team, the 49ers.