The 49ers lost two starting offensive lineman this offseason, including a Pro Bowl guard in Mike Iupati, who went on to sign with a division rival.
It is a group San Francisco could use help at, and they may be looking to acquire it, according to a national report.
The 49ers are one of 'four main teams' looking at Evan Mathis, a Pro Bowl guard recently let go by the Eagles, says ESPN's John Clayton.
The Miami Dolphins, Indianapolis Colts and the Kansas City Chiefs are the three other teams reportedly showing interest.
Mathis, 33, played for Philadelphia from 2011-2014.
The 6-foot-5, 298-pound offensive lineman was originally third round pick back in 2005.
Mathis has played for four teams over his career, suiting up for Carolina, Miami and Cincinnati, in addition to the Eagles.
He is a two-time Pro Bowler and one-time first-team All-Pro.
San Francisco currently has over $10 million in salary cap space.