On Wednesday, 49ers head coach Jim Harbaugh was asked if he's concerned about the Seahawks' multitude of PED-related suspensions.
"Is it a concern? I've definitely noticed it," Harbaugh said.
"You don't know what it is. I mean, even when people say what it is, you don't know that's what it is. It's this thrown out or it's that. But that's usually the agents or the players themselves saying, for example, Adderall. The NFL doesn't release what it actually is. You have no idea. You're taking somebody at their word and I'm not sure you can take them at their word, understanding the circumstances."
On Thursday, Dave Mahler of Sports Radio KJR in Seattle asked Seahawks cornerback Brandon Browner if he had heard Harbaugh's comments.
Browner had not, so Mahler summarized Harbaugh's words, prompting the following response from Browner:
"I don't have anything for it. At the end of the day we gotta win football games. He's a coach. He's never gonna be out there lined up against me. I wish he would. I'd put my hands around his neck."
Browner was suspended for the final four games of the 2012 regular season after testing positive for a PED.
The Seahawks have had an NFL-worst five players suspended for taking PEDs since December 2011.
The 49ers and Seahawks first square off Week 2 in Seattle, and again Week 14 in San Francisco.